Hospital management highlights the importance of studying the performance of medical personnel, including doctors, nurses, and other healthcare workers, as well as non-medical staff such as administrative personnel and operational human resource employees. This research aims to analyze the effects of workload, selfefficacy, and work ethic on burnout and work-life balance, and how these factors impact nurses' performance. The study was conducted at an Islamic hospital located on Jl. Ahmad Yani in Surabaya. It employed a quantitative approach by distributing questionnaires using a saturated sampling technique to 135 respondents, consisting of both medical and non-medical employees working at the hospital. The data analysis technique used to test the hypotheses was structural equation modeling (SEM) with the AMOS program.The results revealed that workload and self-efficacy each have a significant negative impact on burnout. Workload significantly negatively affects work-life balance, while self-efficacy significantly positively affects work-life balance. Both self-efficacy and work-life balance significantly positively impact nurses' performance, whereas workload significantly negatively impacts nurses' performance. Work ethic negatively but insignificantly influences burnout and does not significantly positively affect work-life balance or nurses' performance. Additionally, burnout negatively but insignificantly impacts work-life balance.